The geological conditions in the Three Gorges Reservoir area are complex. When the sliding bed primarily consists of Jurassic weak and hard interbedded bedrock, the stress and deformation mechanisms of anti-slide piles become particularly intricate. In this study, the anti-slide pile was divided into loaded and multiple embedded segments. Virtual nodes were established to describe the continuity of rock stratum boundaries along the pile. The internal forces of the anti-slide pile were calculated through iterative solutions. A comprehensive comparison was made between the theoretical calculation results, numerical simulation results, and model test results. The research revealed that the deformation characteristics of anti-slide piles were significantly influenced by stratum conditions. Furthermore, the interaction between the embedded segment of the anti-slide pile and the rock stratum resulted in the formation of two regions characterized by negative compressive stress. A comparison with the model test results revealed that the maximum deformation, maximum bending moment, and maximum shear force at the pile top were all positively correlated with landslide thrust. Bedrock composed entirely of hard rocks exhibited greater stiffness and relatively smaller deformations. Overall, the theoretical model presented in this paper accurately captured the mechanical behavior of anti-slide piles.