The January 7, 2025, MS 6.8 Dingri earthquake in southern Tibet occurred within the active extensional system of the southern Tibetan Plateau. Based on more than 2.9 million P- and S-wave arrivals from 12,300 local earthquakes using an artificial intelligence–based workflow, We employed double-difference seismic tomography (tomoDDMC) and high-precision relocation to image the three-dimensional Vp, Vs, and Vp/Vs structures of the Dingri source region and to obtain high-precision earthquake locations. The relocated seismicity delineates the Dengmocuo Fault (DMCF) as the primary seismogenic fault, with the mainshock hypocenter located at the transition between high- and low-velocity zones. Tomographic results reveal that the DMCF dips steeply in the upper crust and flattens at 10–12 km depth, consistent with an extensional listric fault geometry. Prominent low-Vp and low-Vp/Vs anomalies west of the fault indicate fractured, fluid-influenced felsic rocks, while the low-Vp, low-Vs, and high-Vp/Vs (~1.85) zone beneath Dengmocuo Lake reflects fluid-saturated sediments. Aftershock clusters concentrate in intermediate-Vp (5.2–6.3 km/s) regions, whereas low-velocity or high-Vp/Vs zones show sparse activity, suggesting that fluids and strong heterogeneity limit strain accumulation. These results indicate that the Dingri earthquake resulted from extensional faulting along the DMCF, modulated by upper-crustal heterogeneity and fluid–rock interactions, providing new insights into continental extension and seismogenesis in the southern Tibetan rift system.